Study: Frequent tanning-bed use triples melanoma risk

Melanom

Titelseite der Zeitschrift: Cancer Epidemiology

Die folgende Studie aus der Zeitschrift:

Cancer Epidemiology, Biomarkers & Prevention.

zeigt, dass häufiges Benutzen einer Sonnenbank zur Hautbräunung mit einem erhöhten Risiko einhergeht an einem Malignen Melanom ("schwarzer Hautkrebs") zu erkranken.

Dieses Risiko ist unabhängig vom Alter und vom Gerätetyp.

Diese Untersuchung ist, soweit ich erkennen kann, hinsichtlich des Studiendesigns sehr gut und im Gegensatz zu früheren Untersuchungen wenig anfechtbar. Es wird interessant sein, wie sich jetzt das US-Gesundheitsministerium FDA jetzt dazu stellt.

Indoor Tanning and Risk of Melanoma: A Case-Control Study in a Highly Exposed Population

1. DeAnn Lazovich1,2,

2. Rachel Isaksson Vogel2,

3. Marianne Berwick4,5,

4. Martin A. Weinstock6,7,8,

5. Kristin E. Anderson1,2 and

6. Erin M. Warshaw9,3

Authors' Affiliations:1Division of Epidemiology and Community Health, 2Masonic Cancer Center, and 3Department of Dermatology, University of Minnesota, Minneapolis, Minnesota; 4Department of Internal Medicine and University of New Mexico Cancer Center and 5Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque, New Mexico; 6Dermatoepidemiology Unit, VA Medical Center, 7Department of Dermatology, Rhode Island Hospital, and Departments of 8Dermatology and Community Health, Brown University, Providence, Rhode Island; and 9Department of Dermatology, VA Medical Center, Minneapolis, Minnesota

1. Corresponding Author:

DeAnn Lazovich, Division of Epidemiology and Community Health, University of Minnesota, 1300 South 2nd Street #300, Minneapolis, MN 55454. Phone: 612-626-9099; Fax: 612-624-0315. E-mail: lazov001@umn.edu

Abstract

Background: Indoor tanning has been only weakly associated with melanoma risk; most reports were unable to adjust for sun exposure, confirm a dose-response, or examine specific tanning devices. A population-based case-control study was conducted to address these limitations.

Methods: Cases of invasive cutaneous melanoma, diagnosed in Minnesota between 2004 and 2007 at ages 25 to 59, were ascertained from a statewide cancer registry; age-matched and gender-matched controls were randomly selected from state driver's license lists. Self-administered questionnaires and telephone interviews included information on ever use of indoor tanning, types of device used, initiation age, period of use, dose, duration, and indoor tanning–related burns. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for known melanoma risk factors.

Results: Among 1,167 cases and 1,101 controls, 62.9% of cases and 51.1% of controls had tanned indoors (adjusted OR 1.74; 95% CI, 1.42-2.14). Melanoma risk was pronounced among users of UVB-enhanced (adjusted OR, 2.86; 95% CI, 2.03-4.03) and primarily UVA-emitting devices (adjusted OR, 4.44; 95% CI, 2.45-8.02). Risk increased with use: years (P < 0.006), hours (P < 0.0001), or sessions (P = 0.0002). ORs were elevated within each initiation age category; among indoor tanners, years used was more relevant for melanoma development.

Conclusions: In a highly exposed population, frequent indoor tanning increased melanoma risk, regardless of age when indoor tanning began. Elevated risks were observed across devices.

Impact: This study overcomes some of the limitations of earlier reports and provides strong support for the recent declaration by the IARC that tanning devices are carcinogenic in humans.